SummaryRead the full fact sheet
- Kidney cancer is most common in people over the age of 50 years.
- Most kidney cancers are found when the doctor is checking for something else.
- Surgery is the most common treatment for kidney cancer.
Each year, more than 3,600 Australians find out they have kidney cancer. It makes up about 2.5% of all cancers. It is twice as common in men as in women and is the 6th most diagnosed cancer in Australian men. The risk of kidney cancer increases with age, and most cases occur in people over 50 years old.
Signs and symptoms of kidney cancer
Most people with kidney cancer have no symptoms. Doctors find most kidney cancers when they are checking for something else. Signs and symptoms can include:
- blood in your urine – this may be obvious, or the urine may look dark, rusty or brown
- pain in your lower back or side
- a lump in your abdomen
- constant tiredness
- unexplained weight loss
- (not caused by a or ).
Not everyone with these symptoms has kidney cancer. If you have any of these symptoms or are worried, always see your doctor.
Risk factors for kidney cancer
There are some things that can make you more likely to develop kidney cancer. These are called risk factors and they include:
- – chemicals in cigarettes can cause kidney cancer. Around one in 3 cases of kidney cancer may be due to smoking
- – excess body fat may cause changes in certain hormones that can lead to kidney cancer
- high blood pressure
- – people with end-stage kidney disease
- family history – people who have family members with kidney cancer, especially a sister or brother
- inherited conditions – about 2 to 3% of kidney cancers occur in people who have certain inherited syndromes, including von Hippel-Lindau disease, hereditary papillary RCC and Birt Hogg-Dubé syndrome
- exposure to toxic substances at work – the risk may be higher after regular exposure to some chemicals, such as some metal degreasers, arsenic or cadmium.
Having these risk factors doesn’t mean you will develop kidney cancer. Often there is no clear reason for getting kidney cancer. If you are worried about your risk factors, ask your doctor for advice.
Tests for kidney cancer
- a complete count of the 3 types of blood cells – red blood cells, white blood cells and platelets
- tests to check how your kidneys are working
- blood chemistry tests to measure certain chemicals.
Your doctor might ask you to have further tests. These are some the tests you may have:
- – a scan on the outside of your abdomen to check for cancer
- – a scan that takes pictures of the inside of the body
- – a scan that uses magnetism and radio waves to take pictures of the inside of the body
- bone scan – a scan that uses dye to show changes in your bones
- cystoscopy – (if you have had blood in your urine) the doctor puts a small camera into your bladder to see inside
- – removal of a tissue sample for examination under a microscope. It is a common way to diagnose cancer, but it is not often needed for kidney cancer before treatment. This is because imaging scans are good at showing if a kidney tumour is cancer.
Types of kidney cancer
Most kidney cancers are renal cell carcinoma (RCC), sometimes called renal adenocarcinoma. Usually only one kidney is affected, but in rare cases both kidneys can be affected. As the cancer grows, it can spread to areas near the kidney. It may also spread to other parts of the body, such as the lungs or bones.
RCC is the most common type of kidney cancer, but there are other less common types:
- urothelial carcinoma, sometimes called transitional cell carcinoma, behaves and is treated like , not like RCC
- Wilms tumour, sometimes called nephroblastoma, is the most common type of kidney cancer in younger children, but it is still rare.
Stages and grades of kidney cancer
Stages and grades of cancer describe how far it has spread and how quickly it is growing.
The stage of a cancer means how far it has grown in your body. Your doctor will use the results of your tests to assign a stage.
- Stages 1 and 2 are considered early kidney cancer (only the kidneys are affected).
- Stages 3 and 4 are considered advanced kidney cancer (the cancer has spread beyond the kidneys).
The grade of the cancer means how quickly a cancer might grow. Knowing the grade helps your doctor work out the best treatment plan for you.
There are different systems for grading kidney cancer. The Fuhrman system has been widely used in Australia, but a newer system called the International Society of Urological Pathology (ISUP) system has been introduced. Both systems grade kidney cancer from 1 to 4, with grade 1 being the slowest growing and grade 4 the fastest growing.
Prognosis and survival rates for kidney cancer
When someone is diagnosed with kidney cancer, their doctor will give them a ‘prognosis’. A prognosis is the doctor’s opinion of how likely the cancer will spread and the chances of getting better. A prognosis depends on the type and stage of cancer, as well as the person’s age and general health.
In most cases, the earlier that kidney cancer is diagnosed, the better the chance of successful treatment.
If you have kidney cancer, your doctor will talk to you about your individual situation when working out your prognosis. Every person’s experience is different, and there is support available to you.
Treatment for kidney cancer
Treatment for kidney cancer depends on how quickly the cancer is growing.
Treatment is different for early kidney cancer and advanced kidney cancer.
You might feel confused or unsure about your treatment options and decisions. It’s okay to ask your treatment team to explain the information to you more than once. It’s often okay to take some time to think about your decisions.
Treatment for early kidney cancer
Treatment for early kidney cancer may include:
- active surveillance
- other treatments.
When small tumours are found in the kidney, they are less likely to be aggressive and might not grow during a person’s lifetime. In this case, your doctor might recommend active surveillance, also known as observation. This involves regular ultrasounds or CT scans. If these imaging tests suggest that the tumour has grown at any time, you will be offered treatment.
Surgery is the main treatment for kidney cancer that has not spread outside the kidney. Depending on the type of kidney cancer, the grade and stage of the cancer, and your general health, you might have one of the following operations:
- Removing part of the kidney, sometimes called a partial nephrectomy – this is the most common option for small tumours within the kidney. Only the cancer and a small part of the kidney are removed.
- Removing the whole kidney, sometimes called a radical nephrectomy – this is the most common operation for large tumours. The whole affected kidney, a small part of the ureter and the surrounding fatty tissue are removed. The adrenal gland and nearby lymph nodes might also be removed.
Surgery is the most common treatment for early kidney cancer. If you are not well enough for surgery and the tumour is small, your doctor may recommend another type of treatment:
- Radiofrequency ablation – uses heat from a needle to kill the cancer cells.
- Stereotactic body radiation therapy – uses highly targeted radiation to destroy or damage the cancer cells.
Treatment for advanced kidney cancer
Treatment for advanced kidney cancer may include:
- active surveillance
- targeted therapy
- radiation therapy.
Drugs that reach cancer cells throughout the body are called systemic treatments. Targeted therapy and immunotherapy are the main systemic treatments used to control advanced kidney cancer. Since the development of these more effective systemic treatments, chemotherapy is rarely used for kidney cancer.
Sometimes when kidney cancer has spread it grows so slowly that it won’t cause any problems for a very long time. Because of this your doctor may suggest active surveillance, also known as observation, involving regular ultrasounds or CT scans. If the cancer starts to grow quickly or causes symptoms, your doctor will recommend active treatment.
Surgery to remove kidney cancer when the cancer has spread to other parts of the body is called cytoreductive surgery. This can involve removing the primary cancer in the kidney by nephrectomy, or removing some or all of the tumours that have grown in other parts of the body.
Generally, surgery is not recommended if you are unwell or if the cancer has spread to many places in the body.
This is a type of treatment that attacks specific parts of cancer cells with medicines to stop the cancer growing and spreading. Types of targeted therapy drugs include:
Tyrosine kinase inhibitors (TKIs)
- These drugs block a group of enzymes called tyrosine kinases from sending signals that tell cancer cells to grow. Without this signal, the cancer cells die.
- Approved for use for some types of advanced kidney cancer.
- Taken as a daily tablet. Often given in repeating cycles, with rest periods in-between. Some may be taken for many months or even years.
- These drugs block the mammalian target of rapamycin (mTOR), an enzyme that tells cancer cells to grow and spread.
- Approved for use for some types of advanced kidney cancer that have not responded to TKIs.
- Taken as a daily tablet. May be taken for many months or even years and may be given alone or with a TKI.
Immunotherapy uses your own immune system to treat cancer. Nivolumab is a checkpoint inhibitor used to treat advanced kidney cancer. Nivolumab is usually administered into a vein (intravenously). Ask your doctor for more information about immunotherapy for kidney cancer.
Radiation therapy uses a controlled dose of radiation, such as focused x-ray beams, to kill or damage cancer cells. It is also known as radiotherapy. Radiation therapy might be used in advanced kidney cancer to shrink a tumour and relieve symptoms.
Side effects of treatment for kidney cancer
All cancer treatments can have side effects. Your treatment team will discuss these with you before you start treatment. Talk to your doctor or nurse about any side effects you are experiencing. Some side effects can be upsetting and difficult, but there is help if you need it.
Sexuality and kidney cancer
Having kidney cancer and treatment can change the way you feel about yourself, other people and sex. These changes can be very upsetting and hard to talk about. Doctors and nurses are very understanding and can give you some support. You can ask for a referral to a doctor or therapist who specialises in body image, sex and relationships.
Living with advanced cancer
Advanced cancer usually means cancer that is unlikely to be cured. Some people can live for many months or years with advanced cancer. During this time palliative care services can help.
Most people continue to have treatment for advanced cancer as part of palliative care, as it helps manage the cancer and improve their day-to-day lives. Many people think that palliative care is for people who are dying but palliative care is for any stage of advanced cancer. There are doctors, nurses and other people who specialise in palliative care.
Treatment can include chemotherapy, radiation therapy or another type of treatment. It can help in these ways:
- slow down how fast the cancer is growing
- shrink the cancer
- help you to live more comfortably by managing symptoms, like pain.
Treatment depends on several things:
- where the cancer started
- how far it has spread
- your general health
- your preferences and what you want to do.
Ask your doctor about treatment and palliative care services that may help you.
Support for carers, family and friends
Caring for someone with cancer can be difficult sometimes. If you are caring for someone with kidney cancer, these organisations can help: