Menopause occurs when a woman stops ovulating and her monthly period (menstruation) ceases. Most women reach menopause between the ages of 45 and 55, with the average age being around 51. However, about one per cent of women experience menopause before the age of 40 years. This is known as premature menopause or premature ovarian insufficiency (POI). Menopause between 41 and 45 years of age is called early menopause.
In some cases, early or premature menopause is brought on by surgical removal of the ovaries, or by medical treatments such as radiation therapy and chemotherapy. In the case of POI, the woman’s ovaries spontaneously stop producing eggs and the underlying cause may not always be found. For many women, the loss of their fertility is devastating, particularly if menopause occurs before they have had children.
Most women with premature or early menopause will experience a long period of postmenopausal life. Menopause hormone therapy (MHT)
– also known as hormone replacement therapy (HRT) – will be advised to counteract the health risks of early or premature menopause, such as early onset of osteoporosis and cardiovascular disease, unless there are reasons why a woman is unable to take MHT.
Symptoms of premature and early menopause
The symptoms of early menopause are the same as for menopause at the typical age and can include:
- menstrual cycle changes, including changes to the usual bleeding pattern, particularly irregular bleeding
- hot flushes
- urinary problems, such as increased frequency of urination or incontinence
- dry vagina
- >mood changes
- >weight changes
- aches and pains.
Causes of early or premature menopause
Premature menopause means the woman’s ovaries have spontaneously stopped working before she has reached the age of 40 years. Women can be affected in their teens or early 20s. About one in 1,000 women reach menopause before the age of 30.
Some possible causes include:
- Unknown causes – in the vast majority of cases (60%), the cause can’t be found. This is known as idiopathic premature menopause.
- Autoimmune conditions – about 10 to 30 per cent of affected women have an autoimmune disease such as hypothyroidism, Crohn’s disease, systemic lupus erythematosus or rheumatoid arthritis.
- Genetic conditions – about 5 to 30 per cent of women with early or premature menopause have an affected female relative, which suggests a genetic link. Genetic conditions which can lead to early or premature menopause include:
- galactosaemia – this is when the body cannot convert the carbohydrate galactose into glucose. It is thought that the unconverted galactose could be toxic to the ovaries
- conditions characterised by enzyme problems, such as congenital adrenal hyperplasia
- Turner’s syndrome – this chromosomal abnormality can cause early menopause, but this is usually evident before puberty
- possibly, Fragile X premutation.
- Viral infections – the evidence is inconclusive, but it is thought that a viral infection, such as mumps or cytomegalovirus, could trigger premature menopause in some women.
Menopause can be specifically induced for medical reasons, such as cancer surgery. For example, a woman with ovarian cancer will require surgery to remove her ovaries.
Early menopause can also be triggered by radiation therapy
. About one in two women treated for leukaemia or Hodgkin’s disease will experience menopause early.
In cases of premature menopause caused by cytotoxic treatments such as chemotherapy, the ovaries can sometimes start working again after a period of time. This depends on many factors, including the woman’s age, the types of drugs used and the dosage. Chemotherapy for breast cancer in premenopausal women may also lead to early menopause.
Diagnosis of premature or early menopause
Premature and early menopause is diagnosed using a number of tests including:
- medical history, family history and medical examination
- investigations to rule out other causes of amenorrhoea (absence of periods), such as pregnancy, extreme weight loss, other hormone disturbances and some diseases of the reproductive system
- investigations into other conditions associated with premature or early menopause, such as autoimmune diseases
- genetic tests to check for the presence of genetic conditions associated with premature or early menopause
- blood tests at various stages of the menstrual cycle to check hormone levels.
Treatment for early or premature menopause
There is no treatment available to make the ovaries start working again.
Rarely, the ovaries may spontaneously start working again, for reasons unknown. According to some studies, about one in 10 women who are diagnosed with spontaneous premature menopause get pregnant, for reasons that are not yet clear.
Women with early menopause have a long period of postmenopausal life, which means they are at increased risk of health problems such as early onset of osteoporosis and heart disease. For this reason, it is recommended that they take menopause hormone therapy (MHT) until they reach the typical age of menopause (around 51 years old). MHT treats menopausal symptoms and reduces the risk of early onset of osteoporosis and heart disease.
Emotional impact of early or premature menopause
Premature menopause can be emotionally devastating. Some of the common issues a woman may face include:
- grief at the prospect of not having children
- fear of ‘growing old before her time’
- fears that her partner won’t find her sexually attractive anymore
- self-esteem problems.
Psychological counselling and support groups may help the woman come to terms with her experience.
Where to get help
This page has been produced in consultation with and approved by:
Jean Hailes for Women's Health
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