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Splenomegaly explained
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Splenomegaly means enlargement of the spleen. The spleen is located on the left side of the abdomen. It can be considered as two organs in one, since it:
- Filters the blood and removes abnormal cells, such as old and defective red blood cells.
- Produces disease-fighting components of the immune system, including antibodies and lymphocytes.
The healthy adult spleen weighs around 200g. However, a variety of disorders can cause the spleen to enlarge, sometimes to 2kg or more. Any conditions that cause a rapid breakdown of blood cells, such as any of the haemolytic anaemias, can place great strain on the spleen and make it enlarge. Other causes of splenomegaly include infections, liver disease and some cancers.
Symptoms
Symptoms of splenomegaly include:
- Enlarged spleen, which can be felt by palpating the abdomen
- Other symptoms, depending on the cause.
A range of causes
Since the spleen is involved in so many bodily functions, it is vulnerable to a wide range of disorders. Some of the causes of splenomegaly include:
- Cirrhosis of the liver - which can increase the blood pressure inside the vessels of the spleen.
- Cystic fibrosis - a genetic disorder, characterised by excessive mucus production, particularly in the lungs and pancreas.
- Cytomegalovirus - a common viral infection that causes mild, flu-like symptoms.
- Glandular fever - an infection caused by the Epstein-Barr virus.
- Haemolytic anaemias such as thalassaemia, a genetic disorder that affects the production of the oxygen-carrying protein in red blood cells (haemoglobin).
- Hodgkin’s disease - cancer of the lymphatic system.
- Leukaemia - cancer of the bone marrow that affects the blood cells.
- Lymphoma - cancer of the lymph nodes of the lymphatic system.
- Malaria - a parasite transmitted to humans by the bite of infected mosquitoes.
Diagnosis methods
Diagnosing splenomegaly involves a number of tests, including:
- Physical examination
- Ultrasound or abdominal x-ray
- Computed tomography (CT) scan
- Blood tests, to check for underlying disorders.
Treatment options
Treatment for splenomegaly depends on the underlying condition. For example, radiation therapy and chemotherapy may be used to treat cancers, while regular blood transfusions are needed to manage thalassaemia.
Ruptured spleen
Certain disorders, including glandular fever, can occasionally make the enlarged spleen delicate enough to rupture. A person with splenomegaly should take care to avoid all contact sports and any other activities that could potentially deliver a hard impact to their abdomen. An overzealous palpation of the abdomen or a sudden blow can split the outer capsule of the spleen and cause bleeding into the abdominal cavity. In this instance, surgery to remove the spleen (splenectomy) is needed. The body seems to cope without the spleen, despite this organ’s many vital functions. However, the person may find they have an increased susceptibility to infection following the operation. Their blood may also contain odd-shaped red blood cells. In some cases, it may be possible to leave healthy portions of spleen intact, and only remove the diseased or damaged parts. This allows the spleen to keep performing its usual functions.
Where to get help
Things to remember
- The spleen removes old and abnormal blood cells and contributes immune system components, including antibodies.
- Splenomegaly means enlargement of the spleen.
- Some of the many causes of splenomegaly include leukaemia, lymphoma, Hodgkin’s disease, glandular fever and malaria.
- Treatment depends on the cause.
You might also be interested in:
Glandular fever.
Immune system.
Want to know more?
Go to More information for support groups, related links and references.
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This page has been produced in consultation with, and approved by:
North East Valley Division of General Practice
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Copyight © 1999/2009 State of Victoria. Reproduced from the Better Health Channel (www.betterhealth.vic.gov.au) at no cost with permission of the Victorian Minister for Health. Unauthorised reproduction and other uses comprised in the copyright are prohibited without permission.
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This Better Health Channel fact sheet has passed through a rigorous approval process. For the latest updates and more information visit www.betterhealth.vic.gov.au.
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Fact sheet currently being reviewed.
Last updated: August 2008
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Splenomegaly means enlargement of the spleen. The spleen removes old and abnormal blood cells and contributes immune system components, including antibodies. Causes of splenomegaly include leukaemia, Hodgkin's disease, thalassaemia and glandular fever. Certain disorders, including glandular fever, can occasionally make the enlarged spleen delicate enough to rupture...
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Splenomegaly explained - Better Health ChannelSplenomegaly means enlargement of the spleen. The spleen removes old and abnormal blood cells and contributes immune system components, including antibodies. Causes of splenomegaly include leukaemia, Hodgkin's disease, thalassaemia and glandular fever. Certain disorders, including glandular fever, can occasionally make the enlarged spleen delicate enough to rupture...
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The information published here was accurate at the time of publication and is not intended to take the place of medical advice. Please seek advice from a qualified health care professional.
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