Short bowel syndrome occurs when a person is unable to absorb food nutrients properly due to severe disease or surgical removal of a significant proportion of the small intestine. Common causes of short bowel syndrome include Crohn’s disease and necrotising enterocolitis. Symptoms may include abdominal pain, diarrhoea, fluid retention, weight loss and fatigue.
Short bowel syndrome occurs when a person is unable to absorb food nutrients properly due to problems with their small intestine. This may be because of severe disease or they may have had surgery to remove a significant proportion of the intestine.
The most common causes of short bowel syndrome in infants are abnormalities in the way the intestine has developed and necrotising enterolitis. In adults, common causes include Crohn’s disease and traumatic injury.
The small intestine fails to absorb food nutrients properly
Normally, absorption of food nutrients happens in the small intestine. Food is squeezed from the stomach, through a sphincter (valve) and into the first part of the small intestine (duodenum), where it is mixed with digestive enzymes. Next, muscular contractions (peristalsis) massage the food into the lower parts of the small intestine (jejunum and ileum).
Nutrients are absorbed along the length of the small intestine, which is lined with millions of microscopic, finger-like projections called villi. Each villus is connected to a mesh of capillaries so that nutrients can pass into the bloodstream. Short bowel syndrome refers to the malabsorption of food nutrients due to failure of the small intestine.
The symptoms of short bowel syndrome can include:
- Abdominal pain
- Stools that float or smell particularly bad
- Fluid retention
- Unintended weight loss
- Extreme fatigue.
Complications of malnutrition
A person with short bowel syndrome is likely to be deficient in a range of important nutrients such as calcium, folate, iron, magnesium, vitamin B12 and zinc. Some of the disorders caused by malnutrition include:
- Skin rashes
- Unusual skin sensations
- Increased susceptibility to infections
- Impaired growth and development in children.
A range of causes
The most common causes of short bowel syndrome include:
- Small intestine malfunction – severe abnormality in the way the small intestine functions. This may be caused by a condition or disease such as intestinal pseudo-obstruction, in which the intestine fails to move food and fluid along its length normally and absorption of food is compromised.
- Bowel surgery – may be required to remove a significant proportion of the small bowel due to disease or malformation.
- Necrotising enterocolitis – a condition that tends to target newborns, particularly premature babies, for reasons unknown. Reduced blood supply to the intestinal walls results in the death of the intestinal lining. The dead tissue must then be surgically removed. Around one-third of babies with this condition will die, despite medical treatment.
- Malformation of the intestine – failure of the intestine to develop properly.
- Crohn’s disease – a condition that causes inflammation of the full thickness of the bowel wall and can target any part of the digestive tract, from mouth to anus, for reasons unknown. If the small intestine is affected, absorption of food nutrients will be impaired.
A person can lose more than half of their small intestine before they experience problems such as malnutrition. This shows the remarkable ability of the small intestine to recover and function after disease or extensive surgery, particularly in children. This is called ‘intestinal adaptation’.
After a section of the small intestine is surgically removed and the healthy portions are sewn together, the organ dilates and grows bigger. The villi become larger, so that more food nutrients can be absorbed, and the movement of food along the small intestine (peristalsis) slows to allow more time for absorption of nutrients. The mechanisms behind this adaptation are not well understood. Researchers have discovered that the amino acid glutamine is important in cell regeneration after bowel resection surgery.
If a person has had major bowel surgery and a significant length of small intestine has been removed, they may experience symptoms such as severe diarrhoea and weight loss. These symptoms may indicate that the person has short bowel syndrome. This condition can improve in time, once intestinal adaptation takes place.
Some of the tests to confirm the diagnosis of short bowel syndrome may include:
- Blood tests
- Stool (poo) examinations
- Intestinal biopsies.
Cases of short bowel syndrome that don’t resolve in time need lifelong treatment. The aim of treatment is to provide the correct balance of nutrients and fluid to enable normal growth, weight gain and activity.
Strategies may include:
- Special diet – including foods that are high in kilojoules and nutrients, low in fat and low in residue
- Vitamin and mineral supplements
- Medications to slow peristalsis
- Bile salt-binding medications
- Medications to reduce stomach acid, if too much acid is a contributing factor
- In severe cases, special fluids containing nutrients may be given intravenously (injected directly into the vein)
- In severe cases where these are complications of intravenous nutrition therapy, a small intestine transplant operation may be considered.
Small intestine transplant
Small intestine transplant operations are becoming a clinical reality, rather than experimental treatments. Since the small intestine contains lymphoid tissue, problems of rejection need to be overcome with powerful immunosuppressive drugs.
Where to get help
- Your doctor
- Australian Crohn’s and Colitis Association Tel. (03) 9726 9008
Things to remember
- Short bowel syndrome refers to the malabsorption of food nutrients due to disease or surgical removal of parts of the small intestine.
- Common causes of short bowel syndrome are diseases where a significant proportion of the small intestine has been damaged or surgically removed. This may include Crohn’s disease and necrotising enterocolitis.
- Treatment aims to provide the fluid and nutrients necessary to support health and includes special diets and medications.
You might also be interested in:
- Coeliac disease and gluten sensitivity.
- Crohn's disease and ulcerative colitis.
- Digestive system.
- Gastroenteritis - giardiasis.
- Irritable bowel syndrome (IBS).
Want to know more?
Go to More information for support groups, related links and references.
This page has been produced in consultation with and approved by:
(Logo links to further information)
University of Melbourne
Fact sheet currently being reviewed.
Last reviewed: July 2012
Content on this website is provided for education and information purposes only. Information about a therapy, service, product or treatment does not imply endorsement and is not intended to replace advice from your doctor or other registered health professional. Content has been prepared for Victorian residents and wider Australian audiences, and was accurate at the time of publication. Readers should note that, over time, currency and completeness of the information may change. All users are urged to always seek advice from a registered health care professional for diagnosis and answers to their medical questions.
Content on this website is provided for education and information purposes only. Information about a therapy, service, product or treatment does not imply endorsement and is not intended to replace advice from your qualified health professional. Content has been prepared for Victorian residence and wider Australian audiences, and was accurate at the time of publication. Readers should note that over time currency and completeness of the information may change. All users are urged to always seek advice from a qualified health care professional for diagnosis and answers to their medical questions.
For the latest updates and more information, visit www.betterhealth.vic.gov.au
Copyight © 1999/2014 State of Victoria. Reproduced from the Better Health Channel (www.betterhealth.vic.gov.au) at no cost with permission of the Victorian Minister for Health. Unauthorised reproduction and other uses comprised in the copyright are prohibited without permission.