The kidneys are part of the urinary system. Kidney cancer is more common in people over the age of 55 years and affects more men than women. Surgery is the most common treatment.
The kidneys are part of the body’s urinary system, which filters waste products out of the blood in the form of urine (pee). About 720 Victorians are diagnosed with kidney cancer every year. Kidney cancer is more common in people over the age of 55 years and affects more men than women.
About the kidneys
The kidneys are two bean-shaped organs located on either side of the middle of the back, just under the ribs. As well as filtering blood, the kidneys make three important hormones, which are:
- renin – helps regulate your blood pressure
- calcitol – helps to control your body’s calcium levels
- erythropoietin – stimulates your bone marrow to make red blood cells.
Risks and causes of kidney cancer
The causes of kidney cancer are unknown. However, there are several factors that may increase your risk including:
- Cigarette smoking – around one in three cases may be due to smoking.
- Faulty genes – some people inherit a faulty gene, which puts them at a higher risk of developing kidney cancer.
- Mild pain-relieving medications – such as overuse of medications containing phenacetin. This chemical is not used in modern pain-relieving medications. However, people who took those containing phenacetin in large quantities before it was banned, may still be affected. There is also early-stage research suggesting that others such as paracetamol, aspirin and 'non steroidal anti-inflammatory drugs' (NSAIDs) such as ibuprofen (Nurofen), may slightly increase the risk of kidney cancer. Researchers say it’s unlikely occasional use or low-dose use would be harmful.
- Obesity – having a waist circumference of 100 cm or greater could increase your risk.
- Exposure to asbestos or cadmium – this applies to some people who were exposed to these substances in their jobs.
- People with kidney disease needing regular dialysis – dialysis is a procedure used on people with kidney failure. Dialysis is a technique that removes extra water and waste products from your body, which is what your kidneys would normally do. The longer you are on dialysis, the greater your risk of getting kidney cancer. The increased risk is most likely due to the kidney disease and not directly due to dialysis.
Types of kidney cancer
Around 85 per cent of kidney cancers are renal cell carcinomas. These cancers begin to grow in the lining of one or both kidneys. Without treatment, this type of cancer can spread to other parts of your body.
Other (less common) types of kidney cancer include:
- transitional cell carcinoma – starts in the join between the kidney and its ureter (the tube that drains urine from the kidney into the bladder)
- renal sarcoma – a rare type of kidney cancer
- Wilms’ tumour – a rare type of kidney cancer that affects children.
Symptoms of kidney cancer
In its early stages, when the cancer is very small, you may not have any symptoms. Sometimes, the disease is found by accident, when your doctor is investigating another condition.
In its later stages, when the cancer is larger, symptoms can include:
- blood in the urine (haematuria) – this is the most common symptom
- a pain or ache in the lower back or side
- a lump in the area of the kidney
- unexplained and sudden loss of appetite and weight loss
- fever with sweating.
Diagnosis of kidney cancer
The first tests you will have are blood and urine tests. If your doctor picks up blood in your urine, they may refer you to the hospital to have further tests, including:
- More urine and blood tests – these check for abnormal levels and enzymes that may indicate cancer.
- Ultrasound scan – sound waves create a picture of the inside of the body and can show any growths inside the kidney.
- Intravenous pyelogram (IVP) – an injected dye makes your kidneys more visible during an x-ray and can show any growths in the tubes inside or leading from the kidneys.
- Cystoscopy – a slender tube is inserted into the bladder via the urethra. The doctor can then look for the source of any bleeding.
- Computed tomography (CT) scan – a special x-ray gives a three-dimensional picture of your internal organs.
- Magnetic resonance imaging (MRI) – this is similar to the CT scan, but radio waves and a strong magnetic field are used to give a three-dimensional picture.
- Blood vessel tests (angiogram or venogram) – this looks at blood flow. This helps to plan surgery and find out if the tumour is near any major blood vessels in the kidneys.
- Chest x-ray and bone scan – these tests will check whether or not the cancer has spread to other parts of your body.
- Radioisotope bone scan – a radioactive dye is injected. Cancer activity in the bone cells is then detected using a special machine.
Treatment of kidney cancer
Treatment for kidney cancer will depend on the type of cancer, as well as the stage of the cancer. Treatment may include:
- surgery to remove the whole kidney (radical nephrectomy) – other affected tissues, such as nearby lymph nodes, are also taken out. You can live with only one healthy kidney
- surgery to remove part of your kidney (partial nephrectomy) – this means that the surgeon will only take away the diseased part of the kidney. This is best for people who have renal cell carcinoma in both kidneys, have only one functioning kidney or for some patients with small cancers.
- Arterial embolisation – this is a method of cutting the main blood supply to the cancer.
- Radiotherapy – radiation targets and kills cancer cells. This is not commonly used in people whose kidney cancer is curable.
- Biological therapy – is also known as immunotherapy. This is the use of substances that are naturally produced within the body to encourage the immune system to fight disease. Interferon and interleukin have been used to treat some kidney cancers. While they are ‘natural' substances, they can sometimes cause severe side effects. Immunotherapy is not a standard treatment in Australia for kidney cancer, but is available in some centres.
- Complementary and alternative therapies – when used alongside your conventional cancer treatment, some of these therapies can make you feel better and improve quality of life. Others may not be so helpful and in some cases may be harmful. The Cancer Council Victoria booklet called Understanding complementary therapies can be a useful resource.
All treatments have side effects. These will vary depending on the type of treatment you are having. Many side effects are temporary, but some may be permanent. Your doctor will explain all the possible side effects before your treatment begins.
Research into kidney cancer
Early detection and better treatment have improved survival for people with kidney cancer. Research for kidney cancer is ongoing. The CancerHelp UK website has information about research into kidney cancer.
Clinical trials can test the effectiveness of promising new treatments or new ways of combining cancer treatments. Always discuss treatment options with your doctor.
Your sexuality and kidney cancer
Having kidney cancer and its treatment can affect the way you feel about your body, who you are, your relationships, the way you express yourself sexually and your sexual feelings (your ‘sexuality’). These changes can be very upsetting.
Your medical team should discuss these issues with you before and during your treatment. If you feel you would like to discuss things further, ask your doctor for a referral to a counsellor or call the Cancer Council Helpline on 13 11 20. The Cancer Council Victoria booklet called Sexuality, intimacy and cancer may also be helpful to read.
Caring for someone with cancer
Caring for someone with cancer can be a difficult and emotional time. If you or someone you know is caring for someone with kidney cancer, there is support available. The Cancer Council Victoria booklet called Caring for someone with cancer may also be helpful to read.
When a cure isn't possible
If kidney cancer has been diagnosed in its later stages, the cancer may have spread to the point where a cure is no longer possible. Treatment then focuses on improving quality of life by relieving the symptoms (this is called ‘palliative’ treatment).
You may be given chemotherapy, radiotherapy and surgery to help with this. You may also have medications to relieve pain, nausea and vomiting. The Cancer Council Victoria booklet called Living with advanced cancer may be helpful to read.
Where to get help
- Your doctor
- Cancer Council Helpline Tel. 13 11 20
- Multilingual Cancer Information Line, Victoria Tel. 13 14 50
Things to remember
- Kidney cancer is more common in people over the age of 55 years.
- Most kidney cancers are found when the doctor is checking for something else.
- A person is usually able to live quite normally with just one kidney.
- Surgery is the most common treatment for kidney cancer.
You might also be interested in:
- Asbestos in the home.
- Cancer and food.
- Cancer and heredity.
- Cancer pain management.
- Cancer treatments - chemotherapy.
- Cancer treatments - radiotherapy.
- Kidney disease.
- Kidney stones.
Want to know more?
Go to More information for support groups, related links and references.
This page has been produced in consultation with and approved by:
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The Cancer Council Victoria
Fact sheet currently being reviewed.
Last reviewed: May 2014
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